Controversies in hormone replacement therapy

Controversies over hormone replacement therapy. HRT as a risk factor of breast cancer in postmenopausal women.

Hormone replacement therapy (HRT) was introduced in order to overcome the problems associated with tissue catabolism to which postmenopausal women are particularly prone. However, it is widely accepted that estrogen is essential for breast tumorigenesis. Therefore, the question is raised as to whether HRT in a long perspective can increase the risk of breast cancer development. Moreover, the re...

Hormone replacement therapy.

HRT is indicated for the treatment of moderate ▪ to severe vasomotor and urogenital symptoms associated with menopause. HRT is not recommended for primary prevention of ▪ disease because of increased risk of other adverse events. The use of HRT increases the risk of stroke, venous ▪ thromboembolism (VTE) and gall bladder disease and combined oestrogen progestogen therapy is also associated with...

Hormone replacement therapy.

Perspectives in hormone replacement therapy.

Estrogens have been convincingly shown to be highly effective in preventing and reversing menopause-related conditions, such as hot flushes, urogenital complaints, and postmenopausal bone loss. Observational studies report that long-term, estrogen-containing, postmenopausal hormone replacement therapy (HRT) leads to a substantial reduction in hip fractures, myocardial infarction, and possibly c...

Hormone Replacement Therapy in Menopause

The menopause is understood like a menstruation cease, because of sudden fall in hormone production. Generally, the symptoms at this stage are heat waves, lack of vaginal lubrication, loss of skin elasticity, hormonal changes, intensification of bone decalcification and reduction of libido. In order to alleviate these symptoms there are Hormone Replacement Therapies (HRT) that use synthetic dru...